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刘凤华

作者:时间:2014-12-18点击数:

 

刘凤华,博士,北京农学院动物科技学院教授,动物科学专业及学科负责人,动物科学系主任。动物科技学院基础兽医学学科负责人、基础兽医学、临床兽医学硕士生导师。中国农业大学临床兽医学中西医结合方向合作培养博士生导师。研究方向:畜禽应激及中药调控;中兽药、中药饲料添加剂研制与开发。社会兼职:中兽药产业技术创新战略联盟秘书长,中兽医学会常务理事,副秘书长;家畜环境卫生学会常务理事,副秘书长;兽医食品卫生学分会常务理事。2009年获得首都教育先锋科技创新个人、2010年获得北京市三八红旗奖章。2012年获得北京市师德先进个人。北京市房山区政府农业顾问。

教学成果:

2007.3《家畜环境卫生学》及《家畜环境卫生学实验教材》。(主编)获北京高等教育精品教材证书,北京市教委;2008.8普通高校精品课程建设教材,中国农业大学出版社。

《家畜环境卫生学》为北京高等学校精品课程,2009北京农学院教学成果二等奖,2009首都教育先锋科技创新先进个人称号。

2008.8参编国家十一五规划教材《家畜环境卫生学》,高等教育出版社

2008.4参编国家十一五规划教材《家畜行为学》,高等教育出版社

2008.8参编国家十一五规划教材《畜牧学通论》,高等教育出版社

科研工作

2011-2015年副主持国家十二五科技支撑计划防治畜禽呼吸、消化系统常见病证中兽药创制及应用示范(2011BAD34B01,952万元,农学院子课题经费330万元);

2008~2010年主持国家十一五科技支撑计划中兽药添加剂研制与开发(2008BADB4B07,778万元);

2010~2014年主持农业部行业科技专项“抗家畜生产运输应激中兽药的研制与开发”(201003060,150万)

2006~2010年主持国家十一五科技支撑计划分课题“安全环保型中兽药的研制与应用”抗病毒中兽药研制与开发(2006BAD31B05-2,114万元);

2010-2012 主持北京市教委学术创新团队计划“畜禽中药添加剂的药效学评价与研制开发” (150万元)

2008~2010年主持国家自然科学基金“热应激对猪小肠黏膜结构与功能的影响及其中药调控机制(30771566,35万元)”,副主持国家自然科学基金“胃肠激素与脾失健运相关性及四君子汤调控机理研究(30771591,33万元)”;

2013-2016年主持国家自然科学基金“EGF/EGFR-MAPKs-MicroRNAs在猪小肠黏膜热损伤后的修复机制(31272478,80万元)”,

2005-2007年主持北京市科委重大攻关课题“畜禽抗应激冲剂的研发与推广”(Y0705003041631,150万元,企业另配套30万元),进行新中兽药二类药的研制开发;

2003-2005主持年北京市自然科学基金B类及北京市教委重点课题“清凉冲剂的有效部分及其药理研究”(KZ200310020007,30万元);

2008~2010年主持北京市自然科学基金“热应激对猪肠黏膜屏障功能的影响及其中药调控研究(项目编号:6082007,11万元)”;

1995年、1997年两次次主持2-北京市自然科学基金课题“蛋鸡热应激及其中药调控”(6952008,6972006,共18万元)

1999年主持北京市科委课题“猪的热应激及其中药调控研究” (954414800,15万元),进行国标三类中兽药清凉冲剂的研制开发;

主持由北京市中关村高新技术开发区海淀园创新基金项目“绿色新中兽药的研制开发”(30万元),探讨和推广从饲养管理、到兽医防疫、鸡肉安全评价及肉鸡生产加工中HACCP管理体系建立等方向。

科研成果:

2009年主持的“石香颗粒”, 农业部三类新兽药(2009)新兽药证字37号,农业部新药审评中心(第一完成人)。已经成果转化。

主持禽用系列中兽药10项(四类)新兽药开发并获得新兽药证书。

作为主持人和副主持人进行猪、牛中兽药的开发研制。其中,以第一完成人获得禽用系列中兽药的研发与推广获得北京市人民政府农业推广二等奖,地方科技进步二等奖。

获得国家发明专利“一种用于防治畜禽热应激综合症的药物”,(第一发明人,ZL200710175640.6);“评价暑热证及中药药效的基因芯片”,(第一发明人, ZL20091014954.1);“一种用于提高畜禽生产性能的药物(第二,ZL2007101755535.2)”。有关黄柏生物碱有效部位提取纯化专利“一种黄柏总生物碱的提取方法”,专利登记号(No:200710179815.0)。主编、副主编、参编著作或教材10余部,主编由中国农业科技出版社出版的《天然物饲料添加剂研制指南》,主编《家畜环境卫生学》获得北京市精品教材及普通高等教育十一五精品课程建设教材称号。中国农业出版社出版的《安全优质肉鸡生产》及《安全优质肉羊生产》,《生态养肉鸡》等10多部;在国内外发表论文70多篇。

科研论文(全部为第一作者或通讯作者):

1.Jin Yu, Fenghua Liu, Peng Yin, Xiaoyu Zhu, Guiling Cheng, Ning Wang,An Lu, Weili Luan, Nuowei Zhang, Jiefeng Li, Kaijun Guo, Yulong Yin,Huichuan Wang, , Jianqin Xu. Integrating miRNA and mRNA Expression Profiles in Response to Heat Stress-Induced Injury in Rat Small Intestine. Functional & Integrative Genomics. 2011,11:203-213. IF 3.82.

2.Liu F H, Yin J D, Du M, Yan P S, Xu J Q, Zhu X Y, Yu J. Heat Stress induced Damage to Porcine Small Intestinal Epithelium associated with Down-Regulation of Epithelial Growth Factor (EGF) Signaling. Journal of Animal Science. 2009,6(87):1941-1949 , IF 2.466.

3.Yu Jin, Yin Peng, Liu Fenghua.. Involvement of ERK1/2 signaling pathway in heat stress-induced damage and expression change of growth factors in rat jejunum and IEC-6 cells. International Journal of Hyperthermia. 2010,10; 26(6): 538–555, Corresponding author. IF 2.713.

4.Jin Yu, Peng Yin, Fenghua Liu, Xiaoyu Zhu, Guilin Cheng, An Lu, Weili Luan, Jianqin Xu. Effect of heat stress on porcine small intestine: a study of morphological and gene expression. Comparative Biochemistry and Physiology, Part A 156 (2010) 119–128. IF 2.196.

5.An Lu, Huichuan Wang, Xiaolin Hou, Huanrong Li, Guilin Cheng, Ning Wang, Xiaoyu Zhu, Jin Yu, Weili Luan, Fenghua Liu, Jianqin Xu. Microarray analysis of gene expression profiles of rat small intestine in response to heat stress. Journal of Biomolecular Screening. 2011 16(6):655-67 IF 2. 5.

6.Jiefeng Li, Huanrong Li, Nuowei Zhang, Wuren Ma, Guilin Cheng, Faqiang Liu, Fenghua Liu, Jianqin Xu Effects of Astragalus polysaccharide on peripheral blood lymphocytes in pigs inoculated with Foot-and-mouth disease virus vaccine. International Journal of Biological Macromolecules. 2011 1;49(3):362-8. IF 2.366

7.K. J. Guo, W. Wang, X. Z. Song, F. H. Liu, J. Q. Xu, I. Zoccarato. Antioxidant function of the active components of some traditional Chinese medicines. Journal of Animal Science. 2011, IF 2.5..

8.Xiaoxi Liu, Huanrong Li, An Lu, Yougang Zhong, Xiaolin Hou1,Ning Wang, Dan Jia, Junlan Zan, Hong Zhao, Jianqin Xu, &Fenghua Liu Reduction of intestinal mucosal immune function in heat- stressed rats and bacterial translocation. Journal of Hyperthermia. 2012: EPUB, (SCI: IF1.9).

9.Dan JIA, Fenghua LIU, Weili LUAN, Kaijun GUO, An LU, Jin YU. 2010. The research of apoptosis in the swine small intestine epithelium treated by heat stress. 2010 First international conference on cellular, molecular biology, biophysics and bioengineering. VI: 260-264.(EI收录)

10.Song X Z, Xu J Q, Wang T, Liu F H. Chinese medicine granule affects the absorption and transport of glucose in porcine small intestinal brush border membrane vesicles under heat stress. Asian- Australasian journal of animal sciences. 2009, 20:246-254. IF 0.875 (Corresponding author)

11.Song X Z, Xu J Q, Wang T, Liu F H. Traditional Chinese medicine decoction enhances growth performance and intestinal glucose absorption in heat stressed pigs by up-regulating the expressions of SGLT1 and GLUT2 mRNA. Livestock Science. 128 (2010) 75–81, Corresponding author) IF 1.41

12.Zhu Xiaoyu; Ming Wang; Yujie Wang; Fenghua Liu; Tongquan Yu; Jianqin Xu; Jin Yu. Taguchi approach for anti-heat stress prescription compatibility in mice spleen lymphocytes in vitro. Archives of Pharmacal Research. 2011, 34(7):1125-33 IF 1.588.

13.Anru Wang, Fenghua Liu, Zhepeng Wang, Xue Jiang, Wei Wang, Kedao Teng, Jianqin Xu. Pathological Study of SPF Chickens Experimentally Infected with a Chinese IBDV Strain BC6/85. Asian Journal of Animal and Veterinary Advances. 2010. 6: 36-50.. IF 1.6.

14.Hehui Qiu, Fenghua Liu, Jianqin Xu, Xiaoyu Zhu, Juan Zhao, Yujie Zhang. Effects of Astragalus Polysaccharides on Associated Immune Cells and Cytokines in Immunosuppressive Dogs. Procedia in Vaccinology 2 (2010) 26–33 ISTP

15.GUO Kaijun, LIU Fenghua, LU Lin, Biagini Davide, Lazzaroni Carla and Zoccarato Ivo. Productive Performance of Double-Muscled Piemontese Cull Cows in Finishing Period. Agricultural Sciences in China. 2010, 9(5): 101-105 SSCI

16.Guilin Cheng, Shufang Xu, Defeng Cui, Xin Chen, Fenghua Liu, An Lu, Weili Luan, Jianqin Xu. Antimicrobial activity of main components DADS from Garlic oil against four pathogenic bacteria in animals in vitro. The journal of traditional veterinary medicine. 2010, 18(1): 151-156.

17.Hong Dong, Yougang Zhong, Fenghua Liu, Kai Yang, Jin Yu, Jianqin Xu. Regulating Effects and Mechanisms of Chinese Medicine Decoction on Growth and Gut Hormone Expression in Heat Stressed Pigs。Livestock Science. 10.1016/j.livsci.2011.08.015. 143 (2012), pp. 77-84 IF 1.41

Fenghua Liu, female, Ph.D, full professor of college of animal science and technology, Beijing University of Agriculture, the person in charge of the Animal Science major, the co-tutor for Ph.D. student of Chinese Agriculture University.She is the Deputy General Secretary of Traditional Chinese Veterinary Medicine Industrial Technology Innovation Strategy League.

Research area: livestock environmental stress and regulation with Chinese traditional veterinary medicine, R&D of Chinese traditional veterinary medicine and feed additives.

Work experience:

1983.7- present: successively being an Assistant, a Lecturer, an Associate professor and a full professor in the College of Animal Science, Beijing University of Agriculture; the person in charge of the major of Animal Science.

2004-present: Tutor of Master student in Clinic Veterinary Science and Basal Veterinary Science of Beijing University of Agriculture.

2004-present: Cotutor of Master student and Doctor student in Clinic Veterinary Science and Basal Veterinary Science of China Agricultural University.

Research projects

2011-2015 in charge of National Twelve-Five Technological Supported Plan of China (No. 2011BAD34B0102, 3,30,000 RMB)

2008~2010 in charge of National Eleven-Five Technological Supported Plan of China: “R&D of Feed additives of Traditional Chinese Medicine” (No. 2008BADB4B07,7,780,000 RMB);

2008-2010 in charge of National Natural Science Foundation of China: “Effect of heat stress on the structure and function of epithelial mucosa in swine small intestine” (No. 30771566, 350,000 RMB)

2013-2016 in charge of National Natural Science Foundation of China:“EGF/EGFR-MAPKs-microRNAs pathway mediated repair in heat stress-porcine intestinal mucosa” (31272478,800,000 RMB)

2010-2012 in charge of Ministry of Agriculture, Industry and Technology Project,: Study on Feed additives of Chinese Medicine for animal transportation stress. (201003060,1,500,000 RMB)

2010-2012 in charge of Academic Innovative Group Programs of Beijing Education Committee, “Academic Innovative Group Programs of Feed additives of Chinese Medicine” (1,500,000 RMB)

Main publications

1.Jin Yu, Fenghua Liu, Peng Yin, Xiaoyu Zhu, Guiling Cheng, Ning Wang,An Lu, Weili Luan, Nuowei Zhang, Jiefeng Li, Kaijun Guo, Yulong Yin,Huichuan Wang, , Jianqin Xu. Integrating miRNA and mRNA Expression Profiles in Response to Heat Stress-Induced Injury in Rat Small Intestine. Functional & Integrative Genomics. 2011,11:203-213. IF 3.82.

2.Liu F H, Yin J D, Du M, Yan P S, Xu J Q, Zhu X Y, Yu J. Heat Stress induced Damage to Porcine Small Intestinal Epithelium associated with Down-Regulation of Epithelial Growth Factor (EGF) Signaling. Journal of Animal Science. 2009,6(87):1941-1949 , IF 2.466.

3.Yu Jin, Yin Peng, Liu Fenghua.. Involvement of ERK1/2 signaling pathway in heat stress-induced damage and expression change of growth factors in rat jejunum and IEC-6 cells. International Journal of Hyperthermia. 2010,10; 26(6): 538–555, Corresponding author. IF 2.713.

4.Jin Yu, Peng Yin, Fenghua Liu, Xiaoyu Zhu, Guilin Cheng, An Lu, Weili Luan, Jianqin Xu. Effect of heat stress on porcine small intestine: a study of morphological and gene expression. Comparative Biochemistry and Physiology, Part A 156 (2010) 119–128. IF 2.196.

5.An Lu, Huichuan Wang, Xiaolin Hou, Huanrong Li, Guilin Cheng, Ning Wang, Xiaoyu Zhu, Jin Yu, Weili Luan, Fenghua Liu, Jianqin Xu. Microarray analysis of gene expression profiles of rat small intestine in response to heat stress. Journal of Biomolecular Screening. 2011 16(6):655-67 IF 2. 5.

6.Jiefeng Li, Huanrong Li, Nuowei Zhang, Wuren Ma, Guilin Cheng, Faqiang Liu, Fenghua Liu, Jianqin Xu Effects of Astragalus polysaccharide on peripheral blood lymphocytes in pigs inoculated with Foot-and-mouth disease virus vaccine. International Journal of Biological Macromolecules. 2011 1;49(3):362-8. IF 2.366

7.K. J. Guo, W. Wang, X. Z. Song, F. H. Liu, J. Q. Xu, I. Zoccarato. Antioxidant function of the active components of some traditional Chinese medicines. Journal of Animal Science. 2011, IF 2.5..

8.Xiaoxi Liu, Huanrong Li, An Lu, Yougang Zhong, Xiaolin Hou1,Ning Wang, Dan Jia, Junlan Zan, Hong Zhao, Jianqin Xu, &Fenghua Liu Reduction of intestinal mucosal immune function in heat- stressed rats and bacterial translocation. Journal of Hyperthermia. 2012: EPUB, (SCI: IF1.9).

9.Zhu Xiaoyu; Ming Wang; Yujie Wang; Fenghua Liu; Tongquan Yu; Jianqin Xu; Jin Yu. Taguchi approach for anti-heat stress prescription compatibility in mice spleen lymphocytes in vitro. Archives of Pharmacal Research. 2011, 34(7):1125-33 IF 1.588.

10.Hong Dong, Yougang Zhong, Fenghua Liu, Kai Yang, Jin Yu, Jianqin Xu. Regulating Effects and Mechanisms of Chinese Medicine Decoction on Growth and Gut Hormone Expression in Heat Stressed Pigs。Livestock Science. 10.1016/j.livsci.2011.08.015. 143 (2012), pp. 77-84 IF 1.41

 

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